DETECTION OF FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATE CAUSED BY MUTATION IN THE GYRA GENE

Drug-resistant tuberculosis is a public health concern. TB that drug-resistant to rifampin and isoniazid known as MDR-TB, whereas XDR-TB MDR-TB also resistant second-line medicines, such fluoroquinolones (levofloxacin, ofloxacin, moxifloxacin). rifampin-resistant (RR-TB), of which 78 percent had multidrug-resistant (MDR-TB) (MDR-TB). Fluoroquinolones are class broad-spectrum antimicrobials have become increasingly popular in recent years. activity against Mycobacterium both vitro vivo. might cause resistance if they used inappropriately or excessively. According several investigations, the majority fluoroquinolone-resistant M. isolates (approximately 50-90 percent) mutations gyrA gene QRDR Quinolone Resistance Determination Region. However, genetic involvement various fluoroquinolone remains an unknown mutation pattern isolates. In previous investigation, were discovered at codons 90 94.